What’s the BuzZ about?
PepTalk’s BuzZ Sessions are focused, stimulating discussions in which delegates discuss important and interesting topics related to upstream protein expression and production through downstream scale-up and manufacturing. This is a moderated discussion with brainstorming and interactive problem-solving between scientists from diverse areas who share a common interest in the discussion topic. The discussions are scheduled for:
Wednesday, January 21, 7:30 – 8:15 am
BuzZ Sessions with Continental Breakfast
BuzZ Table 1: Recent Developments in Tools for Protein Production: What's Hot and What Have We Not Got (but Need)
Moderator: Christopher Cooper, DPhil, Founder, Protein Sciences, Enzymogen Consulting
- Alternative proteases for fusion tag removal
- Cost-effective reagent-based QC methods
- Protein-labeling technologies
- Up-and-coming fusion tags and promising expression systems
- Is there one hypothetical reagent that would be transformational to your protein production efforts?
BuzZ Table 2: Revisiting Construct Design, Cloning Strategies, and Expression Systems
Moderator: Rob Meijers, PhD, Head, Biological Discovery, Institute for Protein Innovation
- What is the use of codon optimization? Revisiting gene synthesis
- HTP cloning methods; Golden gate assembly, Gibson cloning, etc
- Expression systems revisited (Old and up and coming)
- Expression chaperones, fusion proteins
- Open source cell lines, vectors and media
BuzZ Table 3: Expanding the bsAb Toolbox through Automated Workflows
Moderator: Alexandra Cabatingan, Resin Sales Specialist, Cytiva
- How MabSelect Mild Elution enables streamlined and reproducible platforms
- Using MagSepharose for high-throughput screening
- Automated downstream applications using AKTA chromatography systems and their impact on workflow efficiency
BuzZ Table 4: Increasing Purification and Characterization Efficiency
Moderator: Gwenny Go, Senior Scientist, Infectious Disease and Vaccines, Merck
- Recent advanced tools and technologies driving purification workflow improvements
- Ensuring the quality of purified proteins: applying diverse analytics and orthogonal measures
- Exploring automated and semi-automated characterization processes. For example, do you trust traditional Western or capillary electrophoresis? Does automated characterization actually save time?
BuzZ Table 5: Trends in Analytical Data
Moderator: Marcel Passon, PhD Researcher, Biopharmaceutical Technology, Technical University of Munich
- Join us for an engaging discussion on emerging trends shaping the future of analytical data.
- Explore how organizations are leveraging advanced analytics to enhance decision-making.
- Learn how AI-driven insights are transforming strategies and enabling smarter, data-driven outcomes.
BuzZ Table 6: Current Control Strategies for Characterization- What is Next?
Moderator: Kevin Zen, PhD, Principal Consultant, Biologics CMC Consulting
- How effective are current control strategies in managing variability and ensuring quality?
- What emerging tools and technologies are shaping the next phase of characterization control?
- What does the future of characterization look like?
BuzZ Table 7: Challenges in Advancing Peptides to the Clinic
Moderator: Raymond S. Norton, PhD, Professor, Monash Institute of Pharmaceutical Sciences, Monash University
- Proteolytic stability
- Pharmacokinetics
- Oral bioavailability
- Cell surface vs intracellular targets
- Cost of goods: synthetic vs recombinant
BuzZ Table 8: Antibody-Based Technologies for CNS Drug Delivery
Moderator: Peter M. Tessier, PhD, Albert M. Mattocks Professor, Pharmaceutical Sciences & Chemical Engineering, University of Michigan
- CD98hc vs transferrin receptor shuttling: pros/cons & applications
- Impact of bispecific antibody properties on CNS delivery efficiency, selectivity, and retention
- Tailoring antibody shuttles to specific CNS drug delivery applications: nucleic acids, proteins, enzymes, IgGs, and more
- Outstanding challenges in biologics delivery to the CNS and future directions
BuzZ Table 9: Engineering Multispecifics for the Clinic: Potency, Safety, and Manufacturability
Moderator: Hamzeh Rahimi, PhD, Scientist, City of Hope National Medical Center
- Safety-by-design mechanisms
- Potency vs. selectivity engineering
- Manufacturability & developability funnel: what are some early predicters of a go/no go?